Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q96GX1
UPID:
TECT2_HUMAN
Alternative names:
-
Alternative UPACC:
Q96GX1; A8K7Y8; B3KPW5; Q9H966
Background:
Tectonic-2, encoded by the gene with accession number Q96GX1, is a crucial component of the tectonic-like complex. This complex is strategically located at the transition zone of primary cilia, serving as a barrier to prevent the diffusion of transmembrane proteins between the cilia and plasma membranes. It plays a pivotal role in the hedgehog signaling pathway, a key regulator of developmental processes.
Therapeutic significance:
Tectonic-2 is implicated in Meckel syndrome 8 and Joubert syndrome 24, disorders characterized by developmental anomalies of the central nervous system, renal cysts, and polydactyly, among other symptoms. Understanding the role of Tectonic-2 could open doors to potential therapeutic strategies for these complex genetic disorders.