Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96HR9
UPID:
REEP6_HUMAN
Alternative names:
Polyposis locus protein 1-like 1
Alternative UPACC:
Q96HR9; A0A1L5BXV3; B2RE01; D6W5Z0; Q96LM0
Background:
Receptor expression-enhancing protein 6, also known as Polyposis locus protein 1-like 1, plays a crucial role in retinal photoreceptor function and survival. It is essential for retinal development and maintains endoplasmic reticulum and mitochondrial homeostasis in rod photoreceptors. This protein also aids in the trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane.
Therapeutic significance:
Linked to Retinitis pigmentosa 77, a retinal dystrophy causing night vision blindness and loss of visual field, understanding the role of Receptor expression-enhancing protein 6 could open doors to potential therapeutic strategies for this autosomal recessive disease.