Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q96HY6
UPID:
DDRGK_HUMAN
Alternative names:
Dashurin; UFM1-binding and PCI domain-containing protein 1
Alternative UPACC:
Q96HY6; A6NIU5; C9JSZ5; Q9BW47
Background:
DDRGK domain-containing protein 1, also known as Dashurin, plays a pivotal role in cellular processes, including reticulophagy, by acting as a substrate adapter for ufmylation. This protein is essential in responding to endoplasmic reticulum stress, facilitating the recruitment of the E3 UFM1-protein ligase UFL1, and promoting the ufmylation of proteins such as RPN1 and RPL26/uL24. Its involvement in regulating the unfolded protein response and essential processes like hematopoiesis and the inflammatory response underscores its biological significance.
Therapeutic significance:
DDRGK domain-containing protein 1's link to Spondyloepimetaphyseal dysplasia, Shohat type, a skeletal dysplasia affecting cartilage development, highlights its therapeutic potential. Understanding its role could lead to novel therapeutic strategies targeting skeletal dysplasias and other related disorders.