Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96IU2
UPID:
ZBED3_HUMAN
Alternative names:
Axin-interacting protein
Alternative UPACC:
Q96IU2
Background:
Zinc finger BED domain-containing protein 3, also known as Axin-interacting protein, plays a pivotal role in the activation of the canonical Wnt/beta-catenin signaling pathway. This protein stabilizes cytoplasmic beta-catenin, facilitating transcription activation of Wnt target genes. It is crucial in early embryogenesis, influencing symmetric division of blastomeres, mitotic spindle positioning, and F-actin filament network organization. Additionally, it modulates cytoskeletal dynamics and cytoplasmic lattice formation, impacting the distribution of cellular organelles.
Therapeutic significance:
Understanding the role of Zinc finger BED domain-containing protein 3 could open doors to potential therapeutic strategies.