Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q96IV0
UPID:
NGLY1_HUMAN
Alternative names:
N-glycanase 1; Peptide:N-glycanase
Alternative UPACC:
Q96IV0; B4DJE9; Q59FB1; Q6PJD8; Q9BVR8; Q9NR70
Background:
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase, also known as N-glycanase 1, plays a crucial role in cellular homeostasis by deglycosylating denatured N-linked glycoproteins in the cytoplasm. This process aids in their proteasome-mediated degradation, targeting misfolded proteins for destruction while sparing native proteins. Its preference for proteins with high-mannose over complex type oligosaccharides underscores its specificity in cellular processes.
Therapeutic significance:
The association of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase with Congenital disorder of deglycosylation 1, a multisystem disorder marked by developmental delay and liver dysfunction, highlights its therapeutic potential. Understanding its role could pave the way for innovative treatments targeting the underlying genetic variants.