Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q96IZ7
UPID:
RSRC1_HUMAN
Alternative names:
Arginine/serine-rich coiled-coil protein 1
Alternative UPACC:
Q96IZ7; A8K2R9; Q96QK2; Q9NZE5
Background:
Serine/Arginine-related protein 53, also known as Arginine/serine-rich coiled-coil protein 1, plays a crucial role in alternative splicing and transcription regulation. It is involved in both constitutive and alternative pre-mRNA splicing and may assist in recognizing the 3' splice site during the second step of splicing.
Therapeutic significance:
This protein is linked to Intellectual developmental disorder, autosomal recessive 70, characterized by impaired intellectual development and behavioral abnormalities. Understanding the role of Serine/Arginine-related protein 53 could open doors to potential therapeutic strategies for this disorder.