Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96J84
UPID:
KIRR1_HUMAN
Alternative names:
Kin of irregular chiasm-like protein 1; Nephrin-like protein 1
Alternative UPACC:
Q96J84; Q5W0F8; Q5XKC6; Q7Z696; Q7Z7N8; Q8TB15; Q9H9N1; Q9NVA5
Background:
Kin of IRRE-like protein 1, also known as Nephrin-like protein 1, plays a crucial role in the glomerular filtration barrier. It ensures the stability of podocyte architecture, vital for kidney function, by maintaining interdigitating foot processes and slit diaphragm junctions.
Therapeutic significance:
Nephrotic syndrome 23, a renal disease leading to severe complications, is linked to mutations in this protein. Understanding its role could pave the way for innovative treatments, potentially halting the progression to chronic kidney disease.