Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q96JG6
UPID:
VPS50_HUMAN
Alternative names:
Coiled-coil domain-containing protein 132; EARP/GARPII complex subunit VPS50
Alternative UPACC:
Q96JG6; B3KX22; D1MQ00; F5H5U7; Q75N07; Q8WVK3; Q9H5C6
Background:
Syndetin, also known as Coiled-coil domain-containing protein 132 or EARP/GARPII complex subunit VPS50, plays a crucial role in the EARP complex, involved in endocytic recycling. This protein ensures the recycling of internalized transferrin receptor (TFRC) to the plasma membrane and is essential for tethering the EARP complex to recycling endosomes, although it does not participate in retrograde transport to the trans-Golgi network.
Therapeutic significance:
Syndetin is linked to a severe neurodevelopmental disorder characterized by microcephaly, seizures, and neonatal cholestasis, suggesting its pivotal role in brain development and function. Understanding the role of Syndetin could open doors to potential therapeutic strategies for this debilitating condition.