Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96KR4
UPID:
LMLN_HUMAN
Alternative names:
Invadolysin
Alternative UPACC:
Q96KR4; B3LDG9; B3LDH0; C9J796; F8WB28; Q96KR5
Background:
Leishmanolysin-like peptidase, also known as Invadolysin, is a metalloprotease with a crucial role in various biological processes. This protein, identified by the accession number Q96KR4, is characterized by its ability to catalyze the cleavage of peptide bonds, a fundamental action in the degradation of proteins.
Therapeutic significance:
Understanding the role of Leishmanolysin-like peptidase could open doors to potential therapeutic strategies. Its involvement in critical biological pathways suggests that modulation of its activity could offer novel approaches to treat diseases.