Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q96L92
UPID:
SNX27_HUMAN
Alternative names:
-
Alternative UPACC:
Q96L92; Q32Q36; Q4AEJ5; Q5VWB0; Q5VWB1; Q5VWB2; Q6IPP6; Q86UB1; Q96D79; Q9H3K8
Background:
Sorting nexin-27 (SNX27) plays a crucial role in the retrograde transport from endosome to plasma membrane, facilitating the recycling of internalized transmembrane proteins. By binding to proteins with a PDZ-binding motif and associating with the retromer complex, SNX27 prevents their degradation in lysosomes and promotes their return to the plasma membrane. Additionally, SNX27's interaction with the WASH complex and phosphatidylinositol-3-phosphate (PtdIns(3P)) membranes underscores its significance in cellular trafficking and natural killer cell polarity.
Therapeutic significance:
Understanding the role of Sorting nexin-27 could open doors to potential therapeutic strategies.