Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q96M20
UPID:
CNBD2_HUMAN
Alternative names:
-
Alternative UPACC:
Q96M20; Q14C79; Q5JWY7; Q5T3S1; Q9BR36; Q9BWY5
Background:
Cyclic nucleotide-binding domain-containing protein 2 is pivotal in male reproductive health, primarily facilitating spermatogenesis and enhancing sperm motility through the regulation of flagellar bending. This protein's intricate role underscores its importance in the development and function of sperm, making it essential for male fertility.
Therapeutic significance:
Understanding the role of Cyclic nucleotide-binding domain-containing protein 2 could open doors to potential therapeutic strategies. Its critical function in sperm development and motility highlights its potential as a target for addressing male infertility issues.