Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q96M94
UPID:
KLH15_HUMAN
Alternative names:
-
Alternative UPACC:
Q96M94; Q32MN3; Q8NDA3; Q96BM6; Q9C0I6
Background:
Kelch-like protein 15 functions as a substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex, targeting proteins such as the serine/threonine-protein phosphatase 2A subunit PPP2R5B and the DNA-end resection factor RBBP8/CtIP for ubiquitination and degradation. This activity is crucial in DNA damage response, promoting DNA repair through non-homologous end joining.
Therapeutic significance:
Kelch-like protein 15 is implicated in Intellectual developmental disorder, X-linked 103, highlighting its role in neurological health. Understanding the role of Kelch-like protein 15 could open doors to potential therapeutic strategies for this and related disorders.