Focused On-demand Library for Cytosolic carboxypeptidase 4

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.

Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.

 Fig. 1. The sreening workflow of Receptor.AI

This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.

Our library stands out due to several important features:

  • The Receptor.AI platform compiles comprehensive data on the target protein, encompassing previous experiments, literature, known ligands, structural details, and more, leading to a higher chance of selecting the most relevant compounds.
  • Advanced molecular simulations on the platform help pinpoint potential binding sites, making the compounds in our focused library ideal for finding allosteric inhibitors and targeting cryptic pockets.
  • Receptor.AI boasts over 50 tailor-made AI models, rigorously tested and proven in various drug discovery projects and research initiatives. They are crafted for efficacy, dependability, and precision, all of which are key in creating our focused libraries.
  • Beyond creating focused libraries, Receptor.AI offers comprehensive services and complete solutions throughout the preclinical drug discovery phase. Our success-based pricing model minimises risk and maximises the mutual benefits of the project's success.







Alternative names:

ATP/GTP-binding protein-like 1; Protein deglutamylase CCP4

Alternative UPACC:

Q96MI9; A0A1C7CYX3; A1A4X5; A6NJH6; C9JHL5


Cytosolic carboxypeptidase 4, also known as ATP/GTP-binding protein-like 1 and Protein deglutamylase CCP4, plays a crucial role in cellular processes through its function as a metallocarboxypeptidase. It is instrumental in the deglutamylation of tubulin and non-tubulin proteins, facilitating the removal of polyglutamate side chains from the gamma-carboxyl group of glutamate residues. This activity is pivotal in the regulation of tubulin protein's C-terminal tail, specifically targeting long-side-chains while sparing the branching point glutamate.

Therapeutic significance:

The association of Cytosolic carboxypeptidase 4 with Corneal dystrophy, Fuchs endothelial, 8, underscores its potential as a target for therapeutic intervention. Understanding the role of Cytosolic carboxypeptidase 4 could open doors to potential therapeutic strategies, particularly in treating corneal diseases characterized by endothelium loss and abnormal collagenous deposition in the Descemet membrane.

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