Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q96MK3
UPID:
FA20A_HUMAN
Alternative names:
-
Alternative UPACC:
Q96MK3; B2RN47; B2RN49; Q9UF95
Background:
Pseudokinase FAM20A plays a pivotal role in the biomineralization of teeth, acting as an allosteric activator of FAM20C. This interaction enhances FAM20C's ability to phosphorylate enamel matrix proteins, crucial for dental enamel development.
Therapeutic significance:
Given its involvement in Amelogenesis imperfecta 1G, a disorder marked by dental anomalies and nephrocalcinosis, targeting FAM20A could offer novel therapeutic avenues for managing this condition.