Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96MT3
UPID:
PRIC1_HUMAN
Alternative names:
REST/NRSF-interacting LIM domain protein 1
Alternative UPACC:
Q96MT3; Q14C83; Q71QF8; Q96N00
Background:
Prickle-like protein 1, alternatively known as REST/NRSF-interacting LIM domain protein 1, plays a pivotal role in the planar cell polarity pathway, crucial for processes such as convergent extension during gastrulation and neural tube closure. This protein's involvement is essential for the nuclear localization of REST, indicating its significant role in cellular functions and developmental processes.
Therapeutic significance:
Prickle-like protein 1 is linked to diseases such as Epilepsy, progressive myoclonic 1B, and Neural tube defects, highlighting its potential as a target for therapeutic intervention. Understanding the role of Prickle-like protein 1 could open doors to potential therapeutic strategies for these conditions.