Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q96MV8
UPID:
ZDH15_HUMAN
Alternative names:
Acyltransferase ZDHHC15; Zinc finger DHHC domain-containing protein 15
Alternative UPACC:
Q96MV8; B3KVG7; Q3SY30; Q6UWH3
Background:
Palmitoyltransferase ZDHHC15, also known as Acyltransferase ZDHHC15 or Zinc finger DHHC domain-containing protein 15, plays a crucial role in cellular processes by catalyzing the addition of palmitate onto various protein substrates. This enzyme is involved in the regulation of retrograde transport from endosomes to the Golgi apparatus, synaptic clustering, and the differentiation of dopaminergic neurons.
Therapeutic significance:
Linked to Intellectual developmental disorder, X-linked 91, ZDHHC15's understanding could open doors to potential therapeutic strategies, offering hope for interventions in intellectual developmental disorders.