Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q96NG3
UPID:
ODAD4_HUMAN
Alternative names:
Tetratricopeptide repeat protein 25
Alternative UPACC:
Q96NG3; Q6NX40; Q6PJ04; Q9H0K5
Background:
Outer dynein arm-docking complex subunit 4, also known as Tetratricopeptide repeat protein 25, plays a pivotal role in the assembly of the outer dynein arm-docking complex (ODA-DC). This complex is crucial for the binding of outer dynein arms (ODA) onto the doublet microtubule, facilitating the essential function of ciliary axoneme in motility.
Therapeutic significance:
The protein's malfunction is linked to Ciliary dyskinesia, primary, 35, a condition characterized by motile cilia abnormalities leading to severe respiratory infections and potentially situs inversus in Kartagener syndrome. Understanding the role of Outer dynein arm-docking complex subunit 4 could open doors to potential therapeutic strategies for these ciliopathies.