Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q96PD5
UPID:
PGRP2_HUMAN
Alternative names:
Peptidoglycan recognition protein 2; Peptidoglycan recognition protein long
Alternative UPACC:
Q96PD5; A8K050; A8K8C7; B2RMZ2; B7ZM33; Q68CK1; Q96N74; Q9UC60
Background:
N-acetylmuramoyl-L-alanine amidase, also known as Peptidoglycan recognition protein 2 and Peptidoglycan recognition protein long, plays a crucial role in immune defense. It digests biologically active peptidoglycan (PGN) into inactive fragments, serving as a scavenger without direct bacteriolytic activity.
Therapeutic significance:
Understanding the role of N-acetylmuramoyl-L-alanine amidase could open doors to potential therapeutic strategies. Its ability to modulate immune responses by degrading peptidoglycan highlights its potential in treating diseases where the immune system plays a key role.