Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q96PU8
UPID:
QKI_HUMAN
Alternative names:
Protein quaking
Alternative UPACC:
Q96PU8; Q2I375; Q5MJQ1; Q969L9; Q96EJ3; Q96KA3; Q96PU6; Q96PU7; Q9P0X6; Q9P0X7; Q9P0X8; Q9P0X9; Q9P0Y0; Q9P0Y1
Background:
The KH domain-containing RNA-binding protein QKI, also known as Protein quaking, plays a pivotal role in myelinization, crucial for proper nervous system function. It binds specific RNA sequences, regulating mRNA stability, pre-mRNA splicing, mRNA export, and protein translation. Essential for oligodendrocyte differentiation and maturation, QKI is a key player in brain health, influencing myelin and oligodendrocyte functionality.
Therapeutic significance:
Understanding the role of KH domain-containing RNA-binding protein QKI could open doors to potential therapeutic strategies, particularly in neurological disorders where myelinization processes are compromised.