Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q96RD6
UPID:
PANX2_HUMAN
Alternative names:
-
Alternative UPACC:
Q96RD6; B7Z684; Q96RD5; Q9UGX8
Background:
Pannexin-2 plays a crucial role as a structural component of gap junctions and hemichannels, facilitating cell-to-cell communication in various tissues. This protein's unique structure and function underscore its importance in maintaining cellular homeostasis and signaling.
Therapeutic significance:
Understanding the role of Pannexin-2 could open doors to potential therapeutic strategies. Its pivotal function in cellular communication highlights its potential as a target for modulating physiological and pathological processes.