Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q96RR4
UPID:
KKCC2_HUMAN
Alternative names:
Calcium/calmodulin-dependent protein kinase kinase beta
Alternative UPACC:
Q96RR4; A8K7Q7; O94883; Q8IUG2; Q8IUG3; Q8N3I4; Q8WY03; Q8WY04; Q8WY05; Q8WY06; Q96RP1; Q96RP2; Q96RR3; Q9BWE9; Q9UER3; Q9UES2; Q9Y5N2
Background:
Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays a pivotal role in cellular processes through a calcium-triggered signaling cascade. It phosphorylates various targets including CAMK1, CAMK4, and AMPK, responding to calcium signals. This kinase is involved in hippocampal activation of CREB1 and influences neurite growth, with different isoforms promoting branching or elongation.
Therapeutic significance:
Understanding the role of Calcium/calmodulin-dependent protein kinase kinase 2 could open doors to potential therapeutic strategies.