Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q96RU8
UPID:
TRIB1_HUMAN
Alternative names:
G-protein-coupled receptor-induced gene 2 protein; SKIP1
Alternative UPACC:
Q96RU8; B4DMM6; C5HU08; O15180; Q9H2Y8
Background:
Tribbles homolog 1 (Trib1), also known as G-protein-coupled receptor-induced gene 2 protein or SKIP1, plays a pivotal role in protein degradation. It achieves this by interacting with COP1 ubiquitin ligase, selectively binding the recognition sequence of CEBPA, and regulating myeloid cell differentiation. Trib1's interaction with MAPK kinases influences the activation of MAP kinases without possessing kinase activity itself.
Therapeutic significance:
Understanding the role of Tribbles homolog 1 could open doors to potential therapeutic strategies by influencing myeloid cell differentiation and macrophage, eosinophil, and neutrophil differentiation, offering insights into immune response regulation.