Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q99436
UPID:
PSB7_HUMAN
Alternative names:
Macropain chain Z; Multicatalytic endopeptidase complex chain Z; Proteasome subunit Z
Alternative UPACC:
Q99436; B4E0P1; Q5TBG6; Q96AG8; Q9BWA7
Background:
Proteasome subunit beta type-7 (PSMB7), also known as Macropain chain Z, Multicatalytic endopeptidase complex chain Z, and Proteasome subunit Z, is a crucial component of the 20S core proteasome complex. This complex is pivotal in the proteolytic degradation of intracellular proteins, playing essential roles in maintaining cellular function by removing misfolded or damaged proteins and those no longer needed. PSMB7 is known for its trypsin-like activity within the 20S core complex.
Therapeutic significance:
Understanding the role of Proteasome subunit beta type-7 could open doors to potential therapeutic strategies.