Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q99551
UPID:
MTEF1_HUMAN
Alternative names:
Mitochondrial transcription termination factor 1
Alternative UPACC:
Q99551; A4D1E3; Q32NF8; Q53H51; Q9BVR7
Background:
Transcription termination factor 1, mitochondrial (MTF1), also known as Mitochondrial transcription termination factor 1, plays a pivotal role in mitochondrial DNA transcription. It binds to a specific DNA region within the tRNA(Leu(uur)) gene, adjacent to the 16S rRNA gene, promoting DNA bending, unwinding, and base flipping. This action is crucial for directing accurate transcription termination, especially for transcripts initiated on the light strand.
Therapeutic significance:
Understanding the role of Transcription termination factor 1, mitochondrial could open doors to potential therapeutic strategies.