Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q99581
UPID:
FEV_HUMAN
Alternative names:
Fifth Ewing variant protein; PC12 ETS domain-containing transcription factor 1
Alternative UPACC:
Q99581
Background:
Protein FEV, also known as Fifth Ewing variant protein and PC12 ETS domain-containing transcription factor 1, plays a crucial role in the nervous system. It functions as a transcriptional regulator, with activities ranging from transcriptional repression to the differentiation and maintenance of central serotonergic neurons, which are essential for cell growth and neural function.
Therapeutic significance:
Given its involvement in the differentiation and maintenance of serotonergic neurons, understanding the role of Protein FEV could open doors to potential therapeutic strategies for neurological disorders and conditions related to serotonergic system dysfunction.