Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q99784
UPID:
NOE1_HUMAN
Alternative names:
Neuronal olfactomedin-related ER localized protein; Olfactomedin-1
Alternative UPACC:
Q99784; Q53XZ8; Q6IMJ4; Q6IMJ5; Q8N8R0; Q969S7; Q99452
Background:
Noelin, also known as Neuronal olfactomedin-related ER localized protein or Olfactomedin-1, plays a crucial role in the central nervous system's development. It regulates axonal growth by inhibiting the interaction between RTN4R and LINGO1, preventing axon growth cone collapse. Additionally, Noelin is pivotal in neural crest cell production and normal olfactory responses.
Therapeutic significance:
Understanding the role of Noelin could open doors to potential therapeutic strategies. Its involvement in axonal growth and neural crest cell production highlights its significance in neural development and regeneration, offering a promising avenue for research into neurological disorders.