Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q99829
UPID:
CPNE1_HUMAN
Alternative names:
Chromobindin 17; Copine I
Alternative UPACC:
Q99829; E1P5Q4; Q6IBL3; Q9H243; Q9NTZ7
Background:
Copine-1, also known as Chromobindin 17 and Copine I, is a calcium-dependent phospholipid-binding protein integral to various intracellular processes. It is involved in the TNF-alpha receptor signaling pathway and exhibits calcium-dependent phospholipid binding properties. Copine-1 plays a crucial role in neuronal progenitor cell differentiation, inducing neurite outgrowth through an AKT-dependent signaling cascade. Additionally, it may function in membrane trafficking and is involved in TNF-alpha-induced NF-kappa-B transcriptional repression.
Therapeutic significance:
Understanding the role of Copine-1 could open doors to potential therapeutic strategies.