Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q99983
UPID:
OMD_HUMAN
Alternative names:
Keratan sulfate proteoglycan osteomodulin; Osteoadherin
Alternative UPACC:
Q99983; Q5TBF4
Background:
Osteomodulin, also known as Keratan sulfate proteoglycan osteomodulin or Osteoadherin, plays a crucial role in biomineralization processes. It is instrumental in the binding of osteoblasts through the alpha(V)beta(3)-integrin, highlighting its significance in bone formation and integrity.
Therapeutic significance:
Understanding the role of Osteomodulin could open doors to potential therapeutic strategies. Its involvement in bone formation and repair processes makes it a promising target for the development of treatments for bone-related disorders.