Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9BQ24
UPID:
ZFY21_HUMAN
Alternative names:
-
Alternative UPACC:
Q9BQ24; A8K3A4; Q86T05; Q96LT1
Background:
Zinc finger FYVE domain-containing protein 21 plays a crucial role in cell adhesion and motility, essential for the dynamic process of focal adhesion assembly and disassembly. It specifically regulates PTK2/FAK1 dephosphorylation and integrin beta-1/ITGB1 cell surface expression, pivotal for cellular movement and interaction.
Therapeutic significance:
Understanding the role of Zinc finger FYVE domain-containing protein 21 could open doors to potential therapeutic strategies. Its involvement in cell adhesion and motility mechanisms offers a promising avenue for targeting diseases where these processes are dysregulated.