Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9BQA1
UPID:
MEP50_HUMAN
Alternative names:
Androgen receptor cofactor p44; Methylosome protein 50; WD repeat-containing protein 77; p44/Mep50
Alternative UPACC:
Q9BQA1; B3KMW6; B4DP38; Q3LID2; Q53FU2; Q6JZZ5; Q96GK4; Q9BWY3
Background:
Methylosome protein WDR77, also known as Androgen receptor cofactor p44, plays a crucial role in the methylosome complex, modifying specific arginines in spliceosomal Sm proteins and histones. This modification is essential for the assembly of small nuclear ribonucleoprotein core particles, implicating WDR77 in transcription regulation and the methylation of Piwi proteins, vital for their localization to the meiotic nuage.
Therapeutic significance:
Understanding the role of Methylosome protein WDR77 could open doors to potential therapeutic strategies.