Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9BQG1
UPID:
SYT3_HUMAN
Alternative names:
Synaptotagmin III
Alternative UPACC:
Q9BQG1; Q8N5Z1; Q8N640
Background:
Synaptotagmin-3, also known as Synaptotagmin III, plays a pivotal role in the Ca(2+)-dependent exocytosis of secretory vesicles. It functions through Ca(2+) and phospholipid binding to the C2 domain, triggering exocytosis by inducing binding to phospholipid membranes and assembled SNARE-complexes. Additionally, it contributes to dendrite formation by melanocytes, highlighting its significance in cellular communication and structure.
Therapeutic significance:
Understanding the role of Synaptotagmin-3 could open doors to potential therapeutic strategies. Its involvement in exocytosis and dendrite formation positions it as a key player in neurotransmitter release and neural network formation, offering avenues for intervention in neurological disorders.