Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q9BQI0
UPID:
AIF1L_HUMAN
Alternative names:
Ionized calcium-binding adapter molecule 2
Alternative UPACC:
Q9BQI0; B2RBC4; Q6ZR40; Q8NAX7; Q8WU47; Q9H9G0
Background:
Allograft inflammatory factor 1-like, also known as Ionized calcium-binding adapter molecule 2, is a pivotal actin-binding protein. It plays a crucial role in promoting actin bundling, a process essential for cellular structure and movement. Unlike many proteins in its class, it may operate independently of calcium, which suggests a unique mechanism of action.
Therapeutic significance:
Understanding the role of Allograft inflammatory factor 1-like could open doors to potential therapeutic strategies. Its involvement in actin bundling highlights its importance in cellular processes, making it a target of interest for drug discovery efforts aimed at modulating cellular architecture and dynamics.