Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9BRT2
UPID:
UQCC2_HUMAN
Alternative names:
Breast cancer-associated protein SGA-81M; Mitochondrial nucleoid factor 1; Mitochondrial protein M19
Alternative UPACC:
Q9BRT2; B2R4I0
Background:
Ubiquinol-cytochrome-c reductase complex assembly factor 2, also known as Breast cancer-associated protein SGA-81M, Mitochondrial nucleoid factor 1, and Mitochondrial protein M19, plays a crucial role in the assembly of the mitochondrial respiratory chain complex III. This protein is pivotal for oxygen consumption and ATP production, influencing skeletal muscle differentiation and insulin secretion by pancreatic beta-cells.
Therapeutic significance:
Linked to Mitochondrial complex III deficiency, nuclear type 7, characterized by growth retardation, lactic acidosis, and renal dysfunction, this protein's study could lead to novel treatments for mitochondrial disorders.