Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9BT88
UPID:
SYT11_HUMAN
Alternative names:
Synaptotagmin XI
Alternative UPACC:
Q9BT88; Q14998; Q5W0D4; Q68CT5; Q8IXU3; Q96SU2
Background:
Synaptotagmin-11, a member of the Synaptotagmin family, plays a pivotal role in vesicular and membrane trafficking. Unlike its counterparts, it does not bind Ca(2+), but it is instrumental in inhibiting clathrin-mediated and bulk endocytosis. This protein ensures precision in vesicle retrieval, crucial for dopamine transmission, synaptic plasticity, and neuronal development. It also modulates cytokine secretion and phagocytosis in macrophages and microglia, and lysosome exocytosis in astrocytes.
Therapeutic significance:
Understanding the role of Synaptotagmin-11 could open doors to potential therapeutic strategies.