Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9BTP6
UPID:
ZBED2_HUMAN
Alternative names:
-
Alternative UPACC:
Q9BTP6; D3DN62
Background:
Zinc finger BED domain-containing protein 2 plays a crucial role as a transcriptional regulator, utilizing its intrinsic repressor activity to influence gene expression. It competes with IRF1 for binding to a specific consensus sequence in gene promoters, impacting cellular processes. This protein is particularly significant in keratinocyte differentiation, highlighting its importance in skin health and disease.
Therapeutic significance:
Understanding the role of Zinc finger BED domain-containing protein 2 could open doors to potential therapeutic strategies. Its involvement in transcriptional regulation and keratinocyte differentiation presents opportunities for targeted interventions in skin-related conditions.