Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9BUE6
UPID:
ISCA1_HUMAN
Alternative names:
HESB-like domain-containing protein 2; Iron-sulfur assembly protein IscA
Alternative UPACC:
Q9BUE6; B3KP34; B4DJI5; Q8ND75; Q9BZR2
Background:
Iron-sulfur cluster assembly 1 homolog, mitochondrial, also known as HESB-like domain-containing protein 2 or Iron-sulfur assembly protein IscA, plays a crucial role in the maturation of mitochondrial 4Fe-4S proteins. It functions late in the iron-sulfur cluster assembly pathway, likely involved in binding intermediates of Fe/S cluster assembly.
Therapeutic significance:
Linked to Multiple mitochondrial dysfunctions syndrome 5, a severe disorder with early onset neurological deterioration, this protein's dysfunction underscores the importance of its role in mitochondrial health. Understanding the role of Iron-sulfur cluster assembly 1 homolog, mitochondrial could open doors to potential therapeutic strategies.