Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9BUK6
UPID:
MSTO1_HUMAN
Alternative names:
-
Alternative UPACC:
Q9BUK6; Q53GR8; Q5CZ69; Q5T717; Q68CT6; Q7LBZ8; Q7Z3M7; Q7Z558; Q8TE05; Q9NQX2; Q9NVU4
Background:
Protein misato homolog 1 plays a pivotal role in maintaining mitochondrial integrity by regulating mitochondrial distribution and morphology. This protein is essential for mitochondrial fusion and the formation of mitochondrial networks, processes critical for cellular energy production and homeostasis.
Therapeutic significance:
The association of Protein misato homolog 1 with Myopathy, mitochondrial, and ataxia, a neuromuscular disorder characterized by muscle weakness, ataxia, and neurologic features, underscores its potential as a therapeutic target. Understanding the role of Protein misato homolog 1 could open doors to potential therapeutic strategies for treating this debilitating condition.