Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9BV38
UPID:
WDR18_HUMAN
Alternative names:
-
Alternative UPACC:
Q9BV38; O60390; Q9BWR2
Background:
WD repeat-containing protein 18 plays a crucial role in cellular processes as part of the Five Friends of Methylated CHTOP (5FMC) complex, facilitating the transactivation of ZNF148 target genes. It is also a component of the PELP1 complex, aiding in 28S rRNA maturation and pre-60S ribosomal subunit transit. Its involvement in development is suggested by similarity studies.
Therapeutic significance:
Understanding the role of WD repeat-containing protein 18 could open doors to potential therapeutic strategies.