Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9BW61
UPID:
DDA1_HUMAN
Alternative names:
Placenta cross-immune reaction antigen 1
Alternative UPACC:
Q9BW61
Background:
DET1- and DDB1-associated protein 1, also known as Placenta cross-immune reaction antigen 1, plays a crucial role in cellular processes through its involvement in the DCX E3 ubiquitin-protein ligase complexes. These complexes are pivotal for the ubiquitination and subsequent proteasomal degradation of target proteins, ensuring cellular homeostasis and protein quality control.
Therapeutic significance:
Understanding the role of DET1- and DDB1-associated protein 1 could open doors to potential therapeutic strategies. Its critical function in protein degradation pathways highlights its potential as a target for modulating disease-related protein accumulations.