Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9BWJ5
UPID:
SF3B5_HUMAN
Alternative names:
Pre-mRNA-splicing factor SF3b 10 kDa subunit
Alternative UPACC:
Q9BWJ5; B2R568; Q7RTV1
Background:
Splicing factor 3B subunit 5, also known as the Pre-mRNA-splicing factor SF3b 10 kDa subunit, plays a crucial role in pre-mRNA splicing as part of the SF3B complex within the spliceosome. This complex is essential for the assembly of 'A' complex, facilitating the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA, a process vital for the accurate removal of introns from pre-mRNA.
Therapeutic significance:
Understanding the role of Splicing factor 3B subunit 5 could open doors to potential therapeutic strategies.