Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9BWT3
UPID:
PAPOG_HUMAN
Alternative names:
Neo-poly(A) polymerase; Polynucleotide adenylyltransferase gamma; SRP RNA 3'-adenylating enzyme; Signal recognition particle RNA-adenylating enzyme
Alternative UPACC:
Q9BWT3; B2RBH4; Q59G05; Q969N1; Q9H8L2; Q9HAD0
Background:
Poly(A) polymerase gamma, also known as Neo-poly(A) polymerase, plays a crucial role in the post-transcriptional adenylation of mRNA precursors and small RNAs, including SRP RNA and ribosomal 5S RNA. This enzyme's activity is pivotal for RNA stability and function, influencing the efficiency of mRNA translation and the cellular response to stress.
Therapeutic significance:
Understanding the role of Poly(A) polymerase gamma could open doors to potential therapeutic strategies. Its involvement in RNA processing and stability positions it as a key player in cellular homeostasis and disease mechanisms.