Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9BWV7
UPID:
TTLL2_HUMAN
Alternative names:
Testis-specific protein NYD-TSPG; Tubulin--tyrosine ligase-like protein 2
Alternative UPACC:
Q9BWV7; B2RB11; B3KS77; Q7Z6R8; Q86X22
Background:
Probable tubulin polyglutamylase TTLL2, also known as Testis-specific protein NYD-TSPG and Tubulin--tyrosine ligase-like protein 2, is implicated in the modification of tubulin through the addition of glutamate side chains. This process, known as polyglutamylation, is crucial for the functional diversity of tubulin in cellular processes. TTLL2's activity is suggested to be essential in the initiation step of polyglutamylation, indicating a specialized role in this post-translational modification.
Therapeutic significance:
Understanding the role of Probable tubulin polyglutamylase TTLL2 could open doors to potential therapeutic strategies.