Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9BXA6
UPID:
TSSK6_HUMAN
Alternative names:
Cancer/testis antigen 72; Serine/threonine-protein kinase SSTK; Small serine/threonine kinase
Alternative UPACC:
Q9BXA6; B2R9F8; Q6ZMC4; Q96LJ4
Background:
Testis-specific serine/threonine-protein kinase 6, also known as Cancer/testis antigen 72 and Serine/threonine-protein kinase SSTK, plays a crucial role in sperm production and function. It is involved in DNA condensation during postmeiotic chromatin remodeling, a process essential for the proper packaging of DNA in sperm cells.
Therapeutic significance:
Understanding the role of Testis-specific serine/threonine-protein kinase 6 could open doors to potential therapeutic strategies.