Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9BXB5
UPID:
OSB10_HUMAN
Alternative names:
-
Alternative UPACC:
Q9BXB5; B4E212; Q9BTU5
Background:
Oxysterol-binding protein-related protein 10 (ORP10) plays a crucial role in lipid transport between the endoplasmic reticulum and the plasma membrane. It specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate, facilitating the delivery of phosphatidylserine to the plasma membrane. ORP10 also influences lipid biosynthesis negatively and regulates APOB secretion from hepatocytes, while binding to cholesterol, acidic phospholipids, and 25-hydroxycholesterol.
Therapeutic significance:
Understanding the role of Oxysterol-binding protein-related protein 10 could open doors to potential therapeutic strategies.