Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q9BXB7
UPID:
SPT16_HUMAN
Alternative names:
Testis development protein NYD-SP12
Alternative UPACC:
Q9BXB7; Q0R0N4; Q0R0S0; Q0R0W2; Q0R129; Q0R131; Q0R140; Q0R1B8; Q0R1G5; Q0R1I2; Q0R1J6; Q0R1S4; Q0R202; Q0R280; Q0R2F8; Q0R2N6; Q0R2N7; Q0R2R0; Q0R2R1; Q0R2S3; Q0R2S4; Q0R2S5; Q0R2T4; Q0R2T7; Q0R2U2; Q0R2U8; Q0R2U9; Q0R2V5; Q0R2V7; Q8NE67
Background:
Spermatogenesis-associated protein 16, also known as Testis development protein NYD-SP12, plays a pivotal role in male fertility. It is essential for spermiogenesis, particularly in the formation of the sperm acrosome, a critical component for fertilization. This protein's involvement in the arrangement of mitochondria and the shaping of the nuclear structure in spermatozoa underscores its significance in the reproductive process.
Therapeutic significance:
Spermatogenic failure 6, a disorder characterized by defects in spermatogenesis leading to infertility, is directly linked to variations in the SPATA16 gene. Understanding the role of Spermatogenesis-associated protein 16 could open doors to potential therapeutic strategies for treating infertility issues related to spermatogenic defects.