Focused On-demand Library for Tektin-3

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.

The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.

In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.

We employ our advanced, specialised process to create targeted libraries.

Fig. 1. The sreening workflow of Receptor.AI

Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.

Key features that set our library apart include:

The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.
The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.
With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.
Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

partner

Reaxense

upacc

Q9BXF9

UPID:

TEKT3_HUMAN

Alternative names:

Alternative UPACC:

Q9BXF9; B2RAS7; D3DTT0; Q8N5R5; Q96M48

Background:

Tektin-3, a microtubule inner protein, plays a pivotal role in the structure and function of cilia and flagella, essential for cell motility. It forms filamentous polymers within the walls of ciliary and flagellar microtubules, crucial for the proper movement of cells, including spermatozoa. This protein's significance is underscored by its involvement in the dynein-decorated doublet microtubules, highlighting its integral role in cellular dynamics.

Therapeutic significance:

Tektin-3's association with Spermatogenic failure 81, a condition marked by compromised sperm motility and structural anomalies, underscores its therapeutic potential. Understanding Tektin-3's role could pave the way for innovative treatments targeting male infertility, particularly oligoasthenoteratozoospermia. The protein's critical function in sperm mobility offers a promising avenue for developing interventions aimed at enhancing reproductive health.