Focused On-demand Library for Ubiquitin carboxyl-terminal hydrolase 26

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.

We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.

The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.

Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.

Fig. 1. The sreening workflow of Receptor.AI

The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.

Our library distinguishes itself through several key aspects:

The Receptor.AI platform integrates all available data about the target protein, including past experiments, literature data, known ligands, structural information and more. This consolidated approach maximises the probability of prioritising highly relevant compounds.
The platform uses sophisticated molecular simulations to identify possible binding sites so that the compounds in the focused library are suitable for discovering allosteric inhibitors and the binders for cryptic pockets.
The platform integrates over 50 highly customisable AI models, which are thoroughly tested and validated on a multitude of commercial drug discovery programs and research projects. It is designed to be efficient, reliable and accurate. All this power is utilised when producing the focused libraries.
In addition to producing the focused libraries, Receptor.AI provides services and end-to-end solutions at every stage of preclinical drug discovery. The pricing model is success-based, which reduces your risks and leverages the mutual benefits of the project's success.

partner

Reaxense

upacc

Q9BXU7

UPID:

UBP26_HUMAN

Alternative names:

Deubiquitinating enzyme 26; Ubiquitin thioesterase 26; Ubiquitin-specific-processing protease 26

Alternative UPACC:

Q9BXU7; B9WRT6; Q5H9H4

Background:

Ubiquitin carboxyl-terminal hydrolase 26, also known as Deubiquitinating enzyme 26, plays a pivotal role in various biological processes by deubiquitinating and stabilizing components of these processes. It is crucial in somatic cell reprogramming, stabilizing components of the polycomb-repressive complex 1, and enhancing the androgen receptor signaling pathway.

Therapeutic significance:

Its involvement in spermatogenic failure, X-linked, 6, a male infertility disorder, highlights its potential as a target for therapeutic intervention. Understanding the role of Ubiquitin carboxyl-terminal hydrolase 26 could open doors to potential therapeutic strategies.