Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q9BXW4
UPID:
MLP3C_HUMAN
Alternative names:
Autophagy-related protein LC3 C; Autophagy-related ubiquitin-like modifier LC3 C; MAP1 light chain 3-like protein 3; MAP1A/MAP1B light chain 3 C; Microtubule-associated protein 1 light chain 3 gamma
Alternative UPACC:
Q9BXW4; A0PJY8; A2RUP0
Background:
Microtubule-associated proteins 1A/1B light chain 3C, also known as Autophagy-related protein LC3 C, plays a pivotal role in antibacterial autophagy by selectively binding to CALCOCO2. It is instrumental in recruiting ATG8 family members to bacteria like S.typhimurium and may also contribute to aggrephagy, the degradation of ubiquitinated proteins.
Therapeutic significance:
Understanding the role of Microtubule-associated proteins 1A/1B light chain 3C could open doors to potential therapeutic strategies.