Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q9BXW6
UPID:
OSBL1_HUMAN
Alternative names:
-
Alternative UPACC:
Q9BXW6; B7Z7D3; Q9BZF5; Q9NW87
Background:
Oxysterol-binding protein-related protein 1 (ORP1) plays a crucial role in cellular lipid metabolism by binding phospholipids, with a preference for phosphatidic acid and phosphatidylinositol 3-phosphate. It is instrumental in stabilizing GTP-bound RAB7A on late endosomes/lysosomes, thereby modulating the functional properties of late endocytic compartments. Additionally, ORP1 has a binding affinity for 25-hydroxycholesterol and cholesterol, highlighting its significance in cholesterol homeostasis.
Therapeutic significance:
Understanding the role of Oxysterol-binding protein-related protein 1 could open doors to potential therapeutic strategies, particularly in disorders related to lipid metabolism and cholesterol homeostasis.