Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q9BY76
UPID:
ANGL4_HUMAN
Alternative names:
Angiopoietin-like protein 4; Hepatic fibrinogen/angiopoietin-related protein
Alternative UPACC:
Q9BY76; A8MY84; B4E089; D6W670; F5H0I2; Q53HQ6; Q53HU1; Q6UXN0; Q9HBV4; Q9NZU4; Q9Y5B3
Background:
Angiopoietin-related protein 4, also known as Angiopoietin-like protein 4, plays a pivotal role in lipid metabolism by mediating the inactivation of lipoprotein lipase LPL. This action regulates triglyceride clearance from the blood serum. Additionally, it influences glucose homeostasis and insulin sensitivity, and exhibits anti-angiogenic properties by inhibiting endothelial cell proliferation, migration, and vascular leakage.
Therapeutic significance:
Understanding the role of Angiopoietin-related protein 4 could open doors to potential therapeutic strategies.